NEET Biology — Intermediate
Genetics and Heredity
Mendel's Laws:
Law of Dominance: In a heterozygote, dominant allele expresses
Law of Segregation: Allele pairs separate during gamete formation
Law of Independent Assortment: Genes on different chromosomes assort independently
Monohybrid cross (Tt × Tt):
Genotype ratio: 1TT : 2Tt : 1tt = 1:2:1
Phenotype ratio: 3 Tall : 1 short = 3:1
Dihybrid cross (TtRr × TtRr):
Phenotype ratio: 9:3:3:1
Exceptions to Mendel's laws:
Incomplete dominance: pink snapdragon (RR red × rr white → Rr pink)
Co-dominance: AB blood group (both A and B antigens expressed)
Multiple alleles: ABO blood group (Iᴬ, Iᴮ, i alleles)
Linkage: genes on same chromosome tend to be inherited together
Blood Groups (must know for NEET):
Group A: Iᴬ Iᴬ or Iᴬ i → A antigen, anti-B antibody
Group B: Iᴮ Iᴮ or Iᴮ i → B antigen, anti-A antibody
Group AB: Iᴬ Iᴮ → A and B antigens, no antibodies (Universal recipient)
Group O: ii → No antigens, anti-A and anti-B antibodies (Universal donor for RBCs)
Rh factor: +ve = Rh antigen present (D antigen); -ve = absent
Molecular Basis of Inheritance
DNA Structure (Watson-Crick model, 1953):
Double helix, antiparallel strands
Purines: Adenine, Guanine (2 rings)
Pyrimidines: Cytosine, Thymine (1 ring)
Base pairing: A=T (2 H-bonds), G≡C (3 H-bonds)
Chargaff's rule: %A = %T, %G = %C
1 turn = 10 base pairs = 3.4 nm
DNA Replication:
Semi-conservative (Meselson-Stahl experiment proved)
Origin → Helicase unwinds → Primase adds RNA primer
DNA Pol III → synthesizes new strand 5' to 3'
Leading strand: continuous synthesis
Lagging strand: Okazaki fragments, joined by DNA Ligase
DNA Pol I: removes RNA primer, fills gap
Transcription:
DNA → mRNA (in nucleus)
RNA Polymerase unwinds and copies template strand
mRNA: 5'-AUG...codons...stop-3'
Translation:
mRNA + ribosomes + tRNA → protein
Codons: 3 bases = 1 amino acid
AUG = start codon (Met)
UAA, UAG, UGA = stop codons
64 codons (61 amino acids + 3 stop) for 20 amino acids
Genetic code is degenerate (multiple codons per aa) and universal
Ecology
Ecological Levels: Organism → Population → Community → Ecosystem → Biosphere
Population interactions:
Mutualism (+/+): both benefit (lichens, mycorrhizae, pollination)
Commensalism (+/0): one benefits, other neutral (orchids on trees)
Parasitism (+/-): parasite benefits, host harmed (Plasmodium, Ascaris)
Predation (+/-): predator benefits, prey harmed
Competition (-/-): both harmed (interspecific competition → competitive exclusion)
Amensalism (0/-): one harmed, other neutral
Ecological pyramids:
Pyramid of numbers: may be inverted (parasitic food chain)
Pyramid of biomass: may be inverted (ocean: phytoplankton > zooplankton by numbers)
Pyramid of energy: ALWAYS upright (10% law — only 10% energy passes to next level)
Biogeochemical cycles:
Carbon cycle: photosynthesis ↔ respiration + combustion + decomposition
Nitrogen cycle: N₂ → (N₂ fixation) → NH₃ → (nitrification) → NO₂ → NO₃
→ (assimilation) → org N → (denitrification) → N₂
Phosphorus cycle: no gaseous phase (rocks → soil → organisms → decomposers → soil)